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Phenotypic Assays to Identify Agents That Induce Reactive Gliosis: A Counter-Screen to Prioritize Compounds for Preclinical Animal Studies

Astrocyte phenotypes change in a process called reactive gliosis after traumatic central nervous system (CNS) injury. Astrogliosis is characterized by expansion of the glial fibrillary acidic protein (GFAP) cytoskeleton, adoption of stellate morphologies, and differential expression of some extracel...

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Detalhes bibliográficos
Publicado no:Assay Drug Dev Technol
Main Authors: Beckerman, Samuel R., Jimenez, Joaquin E., Shi, Yan, Al-Ali, Hassan, Bixby, John L., Lemmon, Vance P.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555645/
https://ncbi.nlm.nih.gov/pubmed/26230074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2015.654
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