A background Ca(2+) entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling

AIMS: Pathological cardiac hypertrophy is a major predictor for the development of cardiac diseases. It is associated with chronic neurohumoral stimulation and with altered cardiac Ca(2+) signalling in cardiomyocytes. TRPC proteins form agonist-induced cation channels, but their functional role for...

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Veröffentlicht in:Eur Heart J
Hauptverfasser: Camacho Londoño, Juan E., Tian, Qinghai, Hammer, Karin, Schröder, Laura, Camacho Londoño, Julia, Reil, Jan C., He, Tao, Oberhofer, Martin, Mannebach, Stefanie, Mathar, Ilka, Philipp, Stephan E., Tabellion, Wiebke, Schweda, Frank, Dietrich, Alexander, Kaestner, Lars, Laufs, Ulrich, Birnbaumer, Lutz, Flockerzi, Veit, Freichel, Marc, Lipp, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Basic Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554959/
https://ncbi.nlm.nih.gov/pubmed/26069213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv250
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