New Acyloxy Nitroso Compounds with Improved Water Solubility and Nitroxyl (HNO) Release Kinetics and Inhibitors of Platelet Aggregation

New acyloxy nitroso compounds, 4-nitrosotetrahydro-2H-pyran-4-yl 2,2,2-trichloroacetate and 4-nitrosotetrahydro-2H-pyran-4-yl 2,2-dichloropropanoate were prepared. These compounds release HNO under neutral conditions with half-lives between 50 and 120 minutes, identifying these HNO donors as kinetic...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Mohamed, Heba A. H., Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A. A., King, S. Bruce.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554820/
https://ncbi.nlm.nih.gov/pubmed/26228501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.023
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