Direct and Nitroxyl (HNO)-Mediated Reactions of Acyloxy Nitroso Compounds with the Thiol- Containing Proteins Glyceraldehyde 3- Phosphate Dehydrogenase and Alkyl Hydroperoxide Reductase Subunit C

Nitroxyl (HNO) reacts with thiols and this reactivity requires the use of donors with 1-nitrosocyclohexyl acetate, pivalate and trifluoroacetate forming a new group. These acyloxy nitroso compounds inhibit glyceraldehyde 3-phosphate dehydrogenase (GAPDH) by forming a reduction reversible active site...

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Main Authors: Mitroka, Susan, Shoman, Mai E., DuMond, Jenna F., Bellavia, Landon, Aly, Omar M., Abdel-Aziz, Mohamed, Kim-Shapiro, Daniel B., King, S. Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798158/
https://ncbi.nlm.nih.gov/pubmed/23895568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400057r
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