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Direct and Nitroxyl (HNO)-Mediated Reactions of Acyloxy Nitroso Compounds with the Thiol- Containing Proteins Glyceraldehyde 3- Phosphate Dehydrogenase and Alkyl Hydroperoxide Reductase Subunit C
Nitroxyl (HNO) reacts with thiols and this reactivity requires the use of donors with 1-nitrosocyclohexyl acetate, pivalate and trifluoroacetate forming a new group. These acyloxy nitroso compounds inhibit glyceraldehyde 3-phosphate dehydrogenase (GAPDH) by forming a reduction reversible active site...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798158/ https://ncbi.nlm.nih.gov/pubmed/23895568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400057r |
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