A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation

PURPOSE. Inherent instability of the P23H mutant opsin accounts for approximately 10% of autosomal dominant retinitis pigmentosa cases. Our purpose was to develop an overall set of reliable screening strategies to assess if either stabilization or enhanced degradation of mutant rhodopsin could rescu...

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Bibliografiska uppgifter
I publikationen:Invest Ophthalmol Vis Sci
Huvudupphovsmän: Chen, Yuanyuan, Tang, Hong, Seibel, William, Papoian, Ruben, Li, Xiaoyu, Lambert, Nevin A., Palczewski, Krzysztof
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Association for Research in Vision and Ophthalmology 2015
Ämnen:
Biochemistry and Molecular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554260/
https://ncbi.nlm.nih.gov/pubmed/25783607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-16298
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