Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor

T-cell expression levels of CC chemokine receptor 5 (CCR5) are a critical determinant of HIV/AIDS susceptibility, and manifest wide variations (i) between T-cell subsets and among individuals and (ii) in T-cell activation-induced increases in expression levels. We demonstrate that a unifying mechani...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Gornalusse, German G., Mummidi, Srinivas, Gaitan, Alvaro A., Jimenez, Fabio, Ramsuran, Veron, Picton, Anabela, Rogers, Kristen, Manoharan, Muthu Saravanan, Avadhanam, Nymisha, Murthy, Krishna K., Martinez, Hernan, Molano Murillo, Angela, Chykarenko, Zoya A., Hutt, Richard, Daskalakis, Demetre, Shostakovich-Koretskaya, Ludmila, Abdool Karim, Salim, Martin, Jeffrey N., Deeks, Steven G., Hecht, Frederick, Sinclair, Elizabeth, Clark, Robert A., Okulicz, Jason, Valentine, Fred T., Martinson, Neil, Tiemessen, Caroline Tanya, Ndung’u, Thumbi, Hunt, Peter W., He, Weijing, Ahuja, Sunil K.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2015
נושאים:
PNAS Plus
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553789/
https://ncbi.nlm.nih.gov/pubmed/26307764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423228112
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