Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor

T-cell expression levels of CC chemokine receptor 5 (CCR5) are a critical determinant of HIV/AIDS susceptibility, and manifest wide variations (i) between T-cell subsets and among individuals and (ii) in T-cell activation-induced increases in expression levels. We demonstrate that a unifying mechani...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Gornalusse, German G., Mummidi, Srinivas, Gaitan, Alvaro A., Jimenez, Fabio, Ramsuran, Veron, Picton, Anabela, Rogers, Kristen, Manoharan, Muthu Saravanan, Avadhanam, Nymisha, Murthy, Krishna K., Martinez, Hernan, Molano Murillo, Angela, Chykarenko, Zoya A., Hutt, Richard, Daskalakis, Demetre, Shostakovich-Koretskaya, Ludmila, Abdool Karim, Salim, Martin, Jeffrey N., Deeks, Steven G., Hecht, Frederick, Sinclair, Elizabeth, Clark, Robert A., Okulicz, Jason, Valentine, Fred T., Martinson, Neil, Tiemessen, Caroline Tanya, Ndung’u, Thumbi, Hunt, Peter W., He, Weijing, Ahuja, Sunil K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553789/
https://ncbi.nlm.nih.gov/pubmed/26307764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423228112
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