Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor

T-cell expression levels of CC chemokine receptor 5 (CCR5) are a critical determinant of HIV/AIDS susceptibility, and manifest wide variations (i) between T-cell subsets and among individuals and (ii) in T-cell activation-induced increases in expression levels. We demonstrate that a unifying mechani...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gornalusse, German G., Mummidi, Srinivas, Gaitan, Alvaro A., Jimenez, Fabio, Ramsuran, Veron, Picton, Anabela, Rogers, Kristen, Manoharan, Muthu Saravanan, Avadhanam, Nymisha, Murthy, Krishna K., Martinez, Hernan, Molano Murillo, Angela, Chykarenko, Zoya A., Hutt, Richard, Daskalakis, Demetre, Shostakovich-Koretskaya, Ludmila, Abdool Karim, Salim, Martin, Jeffrey N., Deeks, Steven G., Hecht, Frederick, Sinclair, Elizabeth, Clark, Robert A., Okulicz, Jason, Valentine, Fred T., Martinson, Neil, Tiemessen, Caroline Tanya, Ndung’u, Thumbi, Hunt, Peter W., He, Weijing, Ahuja, Sunil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553789/
https://ncbi.nlm.nih.gov/pubmed/26307764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423228112
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