Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor

T-cell expression levels of CC chemokine receptor 5 (CCR5) are a critical determinant of HIV/AIDS susceptibility, and manifest wide variations (i) between T-cell subsets and among individuals and (ii) in T-cell activation-induced increases in expression levels. We demonstrate that a unifying mechani...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gornalusse, German G., Mummidi, Srinivas, Gaitan, Alvaro A., Jimenez, Fabio, Ramsuran, Veron, Picton, Anabela, Rogers, Kristen, Manoharan, Muthu Saravanan, Avadhanam, Nymisha, Murthy, Krishna K., Martinez, Hernan, Molano Murillo, Angela, Chykarenko, Zoya A., Hutt, Richard, Daskalakis, Demetre, Shostakovich-Koretskaya, Ludmila, Abdool Karim, Salim, Martin, Jeffrey N., Deeks, Steven G., Hecht, Frederick, Sinclair, Elizabeth, Clark, Robert A., Okulicz, Jason, Valentine, Fred T., Martinson, Neil, Tiemessen, Caroline Tanya, Ndung’u, Thumbi, Hunt, Peter W., He, Weijing, Ahuja, Sunil K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553789/
https://ncbi.nlm.nih.gov/pubmed/26307764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423228112
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