Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia

BACKGROUND: Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically relevant obs...

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Bibliographische Detailangaben
Veröffentlicht in:Thorax
Hauptverfasser: Hatchwell, Luke, Collison, Adam, Girkin, Jason, Parsons, Kristy, Li, Junyao, Zhang, Jie, Phipps, Simon, Knight, Darryl, Bartlett, Nathan W, Johnston, Sebastian L, Foster, Paul S, Wark, Peter A B, Mattes, Joerg
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2015
Schlagworte:
Respiratory Infection
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552894/
https://ncbi.nlm.nih.gov/pubmed/26108570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2014-205465
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