Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates T(H)2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation

BACKGROUND: Severe asthma is associated with T helper (T(H)) 2 and 17 cell activation, airway neutrophilia and phosphoinositide-3-kinase (PI3K) activation. Asthma exacerbations are commonly caused by rhinovirus (RV) and also associated with PI3K-driven inflammation. Anthraquinone derivatives have be...

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Hauptverfasser: Cesar de Souza Alves, Caio, Collison, Adam, Hatchwell, Luke, Plank, Maximilian, Morten, Matthew, Foster, Paul S., Johnston, Sebastian L., França da Costa, Cristiane, Vieira de Almeida, Mauro, Couto Teixeira, Henrique, Paula Ferreira, Ana, Mattes, Joerg
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818233/
https://ncbi.nlm.nih.gov/pubmed/24223970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079565
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