The tsA58 simian virus 40 large tumor antigen disrupts megakaryocyte differentiation in transgenic mice.

Thrombocytopenia is a condition of multiple etiologies affecting the megakaryocyte lineage. To perturb this lineage in transgenic mice, the tsA58 mutation of the simian virus 40 large tumor antigen was targeted to megakaryocytes using the platelet factor 4 promoter. Ten of 17 transgenic lines genera...

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Huvudupphovsmän: Robinson, M O, Zhou, W, Hokom, M, Danilenko, D M, Hsu, R Y, Atherton, R E, Xu, W, Mu, S, Saris, C J, Swift, S
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1994
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC45527/
https://ncbi.nlm.nih.gov/pubmed/7809123
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