Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia

The eukaryotic translation initiation factor 4E (eIF4E), which is the main composition factor of eIF4F translation initiation complex, influences the growth of tumor through modulating cap-dependent protein translation. Previous studies reported that ribavirin could suppress eIF4E-controlled transla...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Shi, Fangfang, Len, Yamei, Gong, Yuping, Shi, Rui, Yang, Xi, Naren, Duolan, Yan, Tianyou
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552648/
https://ncbi.nlm.nih.gov/pubmed/26317515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136746
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