Three-Dimensional Environment Sustains Hematopoietic Stem Cell Differentiation into Platelet-Producing Megakaryocytes

Hematopoietic stem cells (HSC) differentiate into megakaryocytes (MK), whose function is to release platelets. Attempts to improve in vitro platelet production have been hampered by the low amplification of MK. Providing HSC with an optimal three-dimensional (3D) architecture may favor MK differenti...

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Udgivet i:PLoS One
Main Authors: Pietrzyk-Nivau, Audrey, Poirault-Chassac, Sonia, Gandrille, Sophie, Derkaoui, Sidi-Mohammed, Kauskot, Alexandre, Letourneur, Didier, Le Visage, Catherine, Baruch, Dominique
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552162/
https://ncbi.nlm.nih.gov/pubmed/26313154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136652
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