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Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics

We present a new, rapid method for producing blood platelets in vitro from cultured megakaryocytes based on a microfluidic device. This device consists in a wide array of VWF-coated micropillars. Such pillars act as anchors on megakaryocytes, allowing them to remain trapped in the device and subject...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Blin, Antoine, Le Goff, Anne, Magniez, Aurélie, Poirault-Chassac, Sonia, Teste, Bruno, Sicot, Géraldine, Nguyen, Kim Anh, Hamdi, Feriel S., Reyssat, Mathilde, Baruch, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761988/
https://ncbi.nlm.nih.gov/pubmed/26898346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21700
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