Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism

The calcium-sensing receptor (CaR) modulates renal calcium reabsorption and parathyroid hormone (PTH) secretion and is involved in the etiology of secondary hyperparathyroidism in CKD. Supraphysiologic changes in extracellular pH (pH(o)) modulate CaR responsiveness in HEK-293 (CaR-HEK) cells. Theref...

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Dades bibliogràfiques
Publicat a:J Am Soc Nephrol
Autors principals: Campion, Katherine L., McCormick, Wanda D., Warwicker, Jim, Khayat, Mohd Ezuan Bin, Atkinson-Dell, Rebecca, Steward, Martin C., Delbridge, Leigh W., Mun, Hee-Chang, Conigrave, Arthur D., Ward, Donald T.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2015
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552114/
https://ncbi.nlm.nih.gov/pubmed/25556167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014070653
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