Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism

The calcium-sensing receptor (CaR) modulates renal calcium reabsorption and parathyroid hormone (PTH) secretion and is involved in the etiology of secondary hyperparathyroidism in CKD. Supraphysiologic changes in extracellular pH (pH(o)) modulate CaR responsiveness in HEK-293 (CaR-HEK) cells. Theref...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Campion, Katherine L., McCormick, Wanda D., Warwicker, Jim, Khayat, Mohd Ezuan Bin, Atkinson-Dell, Rebecca, Steward, Martin C., Delbridge, Leigh W., Mun, Hee-Chang, Conigrave, Arthur D., Ward, Donald T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2015
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552114/
https://ncbi.nlm.nih.gov/pubmed/25556167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014070653
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