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Computational Tools for Interpreting Ion Channel pH-Dependence

Activity in many biological systems is mediated by pH, involving proton titratable groups with pKas in the relevant pH range. Experimental analysis of pH-dependence in proteins focusses on particular sidechains, often with mutagenesis of histidine, due to its pKa near to neutral pH. The key question...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Sazanavets, Ivan, Warwicker, Jim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411139/
https://ncbi.nlm.nih.gov/pubmed/25915903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125293
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