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Computational Tools for Interpreting Ion Channel pH-Dependence
Activity in many biological systems is mediated by pH, involving proton titratable groups with pKas in the relevant pH range. Experimental analysis of pH-dependence in proteins focusses on particular sidechains, often with mutagenesis of histidine, due to its pKa near to neutral pH. The key question...
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| 出版年: | PLoS One |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4411139/ https://ncbi.nlm.nih.gov/pubmed/25915903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125293 |
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