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Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics

Protein instability leads to reversible self-association and irreversible aggregation which is a major concern for developing new biopharmaceutical leads. Protein solution behaviour is dictated by the physicochemical properties of the protein and the solution. Optimising protein solutions through ex...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Hebditch, Max, Warwicker, Jim
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374528/
https://ncbi.nlm.nih.gov/pubmed/30760735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36950-8
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