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On the availability of microRNA-induced silencing complexes, saturation of microRNA-binding sites and stoichiometry

Several authors have suggested or inferred that modest changes in microRNA expression can potentiate or impinge on their capacity to mediate gene repression, and that doing so could play a significant role in diseases. Such interpretations are based on several assumptions, namely: (i) changes in mic...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Mayya, Vinay K., Duchaine, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551941/
https://ncbi.nlm.nih.gov/pubmed/26227970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv720
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