Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans

Cytoplasmic poly(A)-binding proteins (PABPs) link mRNA 3′ termini to translation initiation factors, but they also play key roles in mRNA regulation and decay. Reports from mice, zebrafish and Drosophila further involved PABPs in microRNA (miRNA)-mediated silencing, but through seemingly distinct me...

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Udgivet i:Nucleic Acids Res
Main Authors: Flamand, Mathieu N., Wu, Edlyn, Vashisht, Ajay, Jannot, Guillaume, Keiper, Brett D., Simard, Martin J., Wohlschlegel, James, Duchaine, Thomas F.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937315/
https://ncbi.nlm.nih.gov/pubmed/27095199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw276
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