Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans

Cytoplasmic poly(A)-binding proteins (PABPs) link mRNA 3′ termini to translation initiation factors, but they also play key roles in mRNA regulation and decay. Reports from mice, zebrafish and Drosophila further involved PABPs in microRNA (miRNA)-mediated silencing, but through seemingly distinct me...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Flamand, Mathieu N., Wu, Edlyn, Vashisht, Ajay, Jannot, Guillaume, Keiper, Brett D., Simard, Martin J., Wohlschlegel, James, Duchaine, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937315/
https://ncbi.nlm.nih.gov/pubmed/27095199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw276
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