Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer

BACKGROUND: Tapasin is a crucial component of the major histocompatibility (MHC) class I antigen presentation pathway. Defects in this pathway can lead to tumor immune evasion. The aim of this study was to test whether tapasin expression correlates with CD8(+) cytotoxic T lymphocyte (CTL) infiltrati...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Transl Med
Auteurs principaux: Sokol, Lena, Koelzer, Viktor H., Rau, Tilman T., Karamitopoulou, Eva, Zlobec, Inti, Lugli, Alessandro
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551690/
https://ncbi.nlm.nih.gov/pubmed/26310568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0647-1
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