Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer

BACKGROUND: Tapasin is a crucial component of the major histocompatibility (MHC) class I antigen presentation pathway. Defects in this pathway can lead to tumor immune evasion. The aim of this study was to test whether tapasin expression correlates with CD8(+) cytotoxic T lymphocyte (CTL) infiltrati...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Sokol, Lena, Koelzer, Viktor H., Rau, Tilman T., Karamitopoulou, Eva, Zlobec, Inti, Lugli, Alessandro
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551690/
https://ncbi.nlm.nih.gov/pubmed/26310568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0647-1
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