Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease?

PURPOSE: Gluten proteins, the culprits in celiac disease (CD), show striking similarities in primary structure with human salivary proline-rich proteins (PRPs). Both are enriched in pro-line and glutamine residues that often occur consecutively in their sequences. We investigated potential differenc...

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Vydáno v:Proteomics Clin Appl
Hlavní autoři: Tian, Na, Messana, Irene, Leffler, Daniel A., Kelly, Ciaran P., Hansen, Joshua, Cabras, Tiziana, D'Alessandro, Alfredo, Schuppan, Detlef, Castagnola, Massimo, Helmerhorst, Eva J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551613/
https://ncbi.nlm.nih.gov/pubmed/25726832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prca.201400170
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