Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice

We have reported that xeroderma pigmentosum group A (Xpa) gene-knockout mice [Xpa (−/−) mice] are deficient in nucleotide excision repair (NER) and highly sensitive to UV-induced skin carcinogenesis. Although xeroderma pigmentosum group A patients show growth retardation, immature sexual development...

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Publicado en:DNA Repair (Amst)
Autores principales: Nakane, Hironobu, Hirota, Seiichi, Brooks, Philip J., Nakabeppu, Yusaku, Nakatsu, Yoshimichi, Nishimune, Yoshitake, Iino, Akihiro, Tanaka, Kiyoji
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551480/
https://ncbi.nlm.nih.gov/pubmed/18790090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.08.003
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