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And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress

The replisome is important for DNA replication checkpoint activation, but how specific components of the replisome coordinate with ATR to activate Chk1 in human cells remains largely unknown. Here, we demonstrate that And-1, a replisome component, acts together with ATR to activate Chk1. And-1 is ph...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Hao, Jing, de Renty, Christelle, Li, Yongming, Xiao, Haijie, Kemp, Michael G, Han, Zhiyong, DePamphilis, Melvin L, Zhu, Wenge
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551354/
https://ncbi.nlm.nih.gov/pubmed/26082189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488016
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