Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1

TNF is a central actor during inflammation and a well-recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF-induced shock, displays weak expression of TNF receptor 1 protein (TNFR1) but normal mRNA expression,...

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Veröffentlicht in:EMBO Mol Med
Hauptverfasser: Puimège, Leen, Van Hauwermeiren, Filip, Steeland, Sophie, Van Ryckeghem, Sara, Vandewalle, Jolien, Lodens, Sofie, Dejager, Lien, Vandevyver, Sofie, Staelens, Jan, Timmermans, Steven, Vandenbroucke, Roosmarijn E, Libert, Claude
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551340/
https://ncbi.nlm.nih.gov/pubmed/25995337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201405010
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