Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo

A hydroxypyrone-based matrix metalloproteinase (MMP) inhibitor was synthesized and assayed for its inhibitory capacity towards a panel of ten different MMPs. The compound exhibited selective inhibition towards MMP-12. The effects of inhibition of MMP-12 on endotoxemia and inflammation-induced blood-...

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Detaylı Bibliyografya
Yayımlandı:Mediators Inflamm
Asıl Yazarlar: Aerts, J., Vandenbroucke, R. E., Dera, R., Balusu, S., Van Wonterghem, E., Moons, L., Libert, C., Dehaen, W., Arckens, L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi Publishing Corporation 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550771/
https://ncbi.nlm.nih.gov/pubmed/26351407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/510679
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