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A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both Status Epilepticus and Optic Nerve Crush Animal Models

Recently, we showed that matrix metalloproteinase-12 (MMP-12) is highly expressed in microglia and myeloid infiltrates, which are presumably involved in blood–brain barrier (BBB) leakage and subsequent neuronal cell death that follows status epilepticus (SE). Here, we assessed the effects of a hydro...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Vinet, Jonathan, Costa, Anna-Maria, Salinas-Navarro, Manuel, Leo, Giuseppina, Moons, Lieve, Arckens, Lutgarde, Biagini, Giuseppe
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121268/
https://ncbi.nlm.nih.gov/pubmed/30044455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19082178
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