Evaluation of the Impact of Codon Optimization and N-Linked Glycosylation on Functional Immunogenicity of Pfs25 DNA Vaccines Delivered by In Vivo Electroporation in Preclinical Studies in Mice

Plasmodium falciparum sexual stage surface antigen Pfs25 is a well-established candidate for malaria transmission-blocking vaccine development. Immunization with DNA vaccines encoding Pfs25 has been shown to elicit potent antibody responses in mice and nonhuman primates. Studies aimed at further opt...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Clin Vaccine Immunol
Hauptverfasser: Datta, Dibyadyuti, Bansal, Geetha P., Kumar, Rajesh, Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550670/
https://ncbi.nlm.nih.gov/pubmed/26135972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00185-15
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