Comparative functional potency of DNA vaccines encoding Plasmodium falciparum transmission blocking target antigens Pfs48/45 and Pfs25 administered alone or in combination by in vivo electroporation in rhesus macaques

Antibodies recognizing conformational epitopes in Pfs48/45, an antigen expressed on the surface of Plasmodium falciparum gametes and zygotes, have firmly established Pfs48/45 as a promising transmission blocking vaccine (TBV) candidate. However, it has been difficult to reproducibly express Pfs48/45...

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Vydáno v:Vaccine
Hlavní autoři: Datta, Dibyadyuti, Bansal, Geetha P., Grasperge, Brooke, Martin, Dale S., Philipp, Mario, Gerloff, Dietlind, Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728386/
https://ncbi.nlm.nih.gov/pubmed/29132995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.10.042
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