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Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment

Ebolavirus causes sporadic outbreaks of lethal hemorrhagic fever in humans with no currently approved therapy. Cells take up Ebolavirus by macropinocytosis, followed by trafficking through endosomal vesicles. However, few factors controlling endosomal virus movement are known. Here we find that Ebol...

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Publicat a:Science
Autors principals: Sakurai, Yasuteru, Kolokoltsov, Andrey A., Chen, Cheng-Chang, Tidwell, Michael W., Bauta, William E., Klugbauer, Norbert, Grimm, Christian, Wahl-Schott, Christian, Biel, Martin, Davey, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550587/
https://ncbi.nlm.nih.gov/pubmed/25722412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1258758
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