GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway

The causative agent of human African trypanosomiasis, Trypanosoma brucei, lacks de novo purine biosynthesis and depends on purine salvage from the host. The purine salvage pathway is redundant and contains two routes to guanosine-5′-monophosphate (GMP) formation: conversion from xanthosine-5′-monoph...

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Bibliographic Details
Published in:Mol Microbiol
Main Authors: Li, Qiong, Leija, Christopher, Rijo-Ferreira, Filipa, Chen, Jun, Cestari, Igor, Stuart, Kenneth, Tu, Benjamin P., Phillips, Margaret A.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550530/
https://ncbi.nlm.nih.gov/pubmed/26043892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13083
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