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GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway
The causative agent of human African trypanosomiasis, Trypanosoma brucei, lacks de novo purine biosynthesis and depends on purine salvage from the host. The purine salvage pathway is redundant and contains two routes to guanosine-5′-monophosphate (GMP) formation: conversion from xanthosine-5′-monoph...
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| Publicado no: | Mol Microbiol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4550530/ https://ncbi.nlm.nih.gov/pubmed/26043892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13083 |
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