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Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding

RAS proteins are signal transduction gatekeepers that mediate cell growth, survival, and differentiation through interactions with multiple effector proteins. The RAS effector RAS- and RAB-interacting protein 1 (RIN1) activates its own downstream effectors, the small GTPase RAB5 and the tyrosine kin...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Ting, Pamela Y., Johnson, Christian W., Fang, Cong, Cao, Xiaoqing, Graeber, Thomas G., Mattos, Carla, Colicelli, John
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550377/
https://ncbi.nlm.nih.gov/pubmed/25999467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271510
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