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Impact of RING and BRCT Domain Mutations on BRCA1 Protein Stability, Localization, and Recruitment to DNA Damage
Mutations within the tumor suppressor BRCA1 cause the majority of hereditary breast and ovarian cancer cases. The BRCA1 protein is an important regulator of DNA double strand break repair and BRCA1 deficient cells are highly sensitive to ionizing radiation. Furthermore, BRCA1 function may contribute...
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| Publicado en: | Radiat Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4550207/ https://ncbi.nlm.nih.gov/pubmed/20681793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1290.1 |
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