A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

T cell immunity directed against tumor-encoded amino acid substitutions (AAS) occurs in some melanoma patients. This implicates missense mutations (MM) as a source of patient-specific neoantigens. However, a systematic evaluation of these putative neoantigens as validated targets of anti-tumor immun...

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Veröffentlicht in:Science
Hauptverfasser: Carreno, Beatriz M., Magrini, Vincent, Becker-Hapak, Michelle, Kaabinejadian, Saghar, Hundal, Jasreet, Petti, Allegra A., Ly, Amy, Lie, Wen-Rong, Hildebrand, William H., Mardis, Elaine R., Linette, Gerald P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549796/
https://ncbi.nlm.nih.gov/pubmed/25837513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa3828
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