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A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
T cell immunity directed against tumor-encoded amino acid substitutions (AAS) occurs in some melanoma patients. This implicates missense mutations (MM) as a source of patient-specific neoantigens. However, a systematic evaluation of these putative neoantigens as validated targets of anti-tumor immun...
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| Publié dans: | Science |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4549796/ https://ncbi.nlm.nih.gov/pubmed/25837513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa3828 |
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