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The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken

Highly pathogenic avian influenza viruses (HPAIV) cause devastating losses in gallinaceous poultry world-wide and raised concerns of a novel pandemic. HPAIV develop from low-pathogenic precursors by acquisition of a polybasic HA cleavage site (HACS), the prime virulence determinant. Beside that HACS...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Stech, Olga, Veits, Jutta, Abdelwhab, El-Sayed M., Wessels, Ute, Mettenleiter, Thomas C., Stech, Jürgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549673/
https://ncbi.nlm.nih.gov/pubmed/26306544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13493
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