HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome

The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. Structural analysis of HLA-E/NKG2A complexes visualized fine-tuning of protective immune responses through AA interactions between HLA-E, the bound peptide, and NKG...

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Udgivet i:Stem Cells Int
Main Authors: Kraemer, Thomas, Celik, Alexander A., Huyton, Trevor, Kunze-Schumacher, Heike, Blasczyk, Rainer, Bade-Döding, Christina
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549550/
https://ncbi.nlm.nih.gov/pubmed/26366178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/346714
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