Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression

Lamin B1 is a component of the nuclear lamina and plays a critical role in maintaining nuclear architecture, regulating gene expression and modulating chromatin positioning. We have previously shown that LMNB1 gene duplications cause autosomal dominant leukodystrophy (ADLD), a fatal adult onset demy...

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Pubblicato in:J Neurosci
Autori principali: Rolyan, Harshvardhan, Tyurina, Yulia Y., Hernandez, Marylens, Amoscato, Andrew A., Sparvero, Louis J., Nmezi, Bruce C., Lu, Yue, Estécio, Marcos R. H., Lin, Kevin, Chen, Junda, He, Rong-Rong, Gong, Pin, Rigatti, Lora H., Dupree, Jeffrey, Bayır, Hülya, Kagan, Valerian E., Casaccia, Patrizia, Padiath, Quasar S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549407/
https://ncbi.nlm.nih.gov/pubmed/26311780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1668-15.2015
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