p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating with the Notch Transcriptional Complex via MAML1()

p53 and Notch-1 play important roles in breast cancer biology. Notch-1 inhibits p53 activity in cervical and breast cancer cells. Conversely, p53 inhibits Notch activity in T-cells but stimulates it in human keratinocytes. Notch co-activator MAML1 binds p53 and functions as a p53 co-activator. We st...

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Publicat a:J Cell Physiol
Autors principals: Yun, Jieun, Espinoza, Ingrid, Pannuti, Antonio, Romero, Damian, Martinez, Luis, Caskey, Mary, Stanculescu, Adina, Bocchetta, Maurizio, Rizzo, Paola, Band, Vimla, Band, Hamid, Kim, Hwan Mook, Park, Song-Kyu, Kang, Keon Wook, Avantaggiati, Maria Laura, Gomez, Christian R., Golde, Todd, Osborne, Barbara, Miele, Lucio
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549197/
https://ncbi.nlm.nih.gov/pubmed/26033683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25052
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