NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function

NF-κB is generally believed to be pro-tumorigenic. Here, we report a tumor-suppressive function for NF-κB1, the prototypical member of NF-κB. While NF-κB1 down-regulation is associated with high lung cancer risk in humans and poor patient survival, NF-κB1 deficient mice are more vulnerable to lung t...

Full description

Saved in:

Bibliographic Details
Published in:	Oncogene
Main Authors:	Sun, Fan, Qu, Zhaoxia, Xiao, Yadong, Zhou, Jingjiao, Burns, Timothy F., Stabile, Laura P., Siegfried, Jill M., Xiao, Gutian
Format:	Artigo
Language:	Inglês
Published:	2015
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4548811/ https://ncbi.nlm.nih.gov/pubmed/26300007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.299
Tags:	Add Tag No Tags, Be the first to tag this record!

NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function

Similar Items