A porcine model system of BRCA1 driven breast cancer

BRCA1 is a breast and ovarian tumor suppressor. Hereditary mutations in BRCA1 result in a predisposition to breast cancer, and BRCA1 expression is down-regulated in ~30% of sporadic cases. The function of BRCA1 remains poorly understood, but it appears to play an important role in DNA repair and the...

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Bibliografiska uppgifter
I publikationen:Front Genet
Huvudupphovsmän: Donninger, Howard, Hobbing, Katharine, Schmidt, M. L., Walters, Eric, Rund, Laurie, Schook, Larry, Clark, Geoffrey J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2015
Ämnen:
Oncology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548227/
https://ncbi.nlm.nih.gov/pubmed/26379698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00269
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