Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication

AIM: To screen and investigate the effective gRNAs against hepatitis B virus (HBV) of genotypes A-D. METHODS: A total of 15 gRNAs against HBV of genotypes A-D were designed. Eleven combinations of two above gRNAs (dual-gRNAs) covering the regulatory region of HBV were chosen. The efficiency of each...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:World J Gastroenterol
Main Authors: Wang, Jie, Xu, Zhong-Wei, Liu, Shuang, Zhang, Rui-Yang, Ding, Shan-Long, Xie, Xiao-Meng, Long, Lu, Chen, Xiang-Mei, Zhuang, Hui, Lu, Feng-Min
Format: Artigo
Jezik:Inglês
Izdano: Baishideng Publishing Group Inc 2015
Teme:
Basic Study
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548116/
https://ncbi.nlm.nih.gov/pubmed/26327763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i32.9554
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