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Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication
AIM: To screen and investigate the effective gRNAs against hepatitis B virus (HBV) of genotypes A-D. METHODS: A total of 15 gRNAs against HBV of genotypes A-D were designed. Eleven combinations of two above gRNAs (dual-gRNAs) covering the regulatory region of HBV were chosen. The efficiency of each...
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| Publié dans: | World J Gastroenterol |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Baishideng Publishing Group Inc
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4548116/ https://ncbi.nlm.nih.gov/pubmed/26327763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i32.9554 |
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