The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity

Multifactorial mechanisms comprising countless cellular factors and virus-encoded transactivators regulate the transcription of HIV-1 (HIV). Since poly(ADP-ribose) polymerase 1 (PARP-1) regulates numerous genes through its interaction with various transcription factors, inhibition of PARP-1 has surf...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Rom, Slava, Reichenbach, Nancy L., Dykstra, Holly, Persidsky, Yuri
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548080/
https://ncbi.nlm.nih.gov/pubmed/26379653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00878
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