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Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
MT1-MMP (MMP14) is a collagenolytic enzyme located at the cell surface and implicated in extracellular matrix (ECM) remodeling. Mmp14(−/−) mice present dwarfism, bone abnormalities, and premature death. We demonstrate herein that the loss of MT1-MMP also causes cardiac defects and severe metabolic c...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547893/ https://ncbi.nlm.nih.gov/pubmed/25991604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490594 |
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