Prophylactic Injection of Recombinant Alpha-Enolase Reduces Arthritis Severity in the Collagen-Induced Arthritis Mice Model

OBJECTIVE: To evaluate the ability of the glycolytic enzyme alpha-enolase (ENO1) or its immunodominant peptide (pEP1) to reduce the severity of CIA in DBA/1 mice when injected in a prophylactic way. METHODS: Mice were treated with mouse ENO1 or pEP1 one day prior to collagen II immunization. Clinica...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Guillou, Clément, Derambure, Céline, Fréret, Manuel, Verdet, Mathieu, Avenel, Gilles, Golinski, Marie-Laure, Sabourin, Jean-Christophe, Loarer, François Le, Adriouch, Sahil, Boyer, Olivier, Lequerré, Thierry, Vittecoq, Olivier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547710/
https://ncbi.nlm.nih.gov/pubmed/26302382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136359
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