Soluble alpha-enolase activates monocytes by CD14-dependent TLR4 signalling pathway and exhibits a dual function

Rheumatoid arthritis (RA) is the most common form of chronic inflammatory rheumatism. Identifying auto-antigens targeted by RA auto-antibodies is of major interest. Alpha-enolase (ENO1) is considered to be a pivotal auto-antigen in early RA but its pathophysiologic role remains unknown. The main obj...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Guillou, Clément, Fréret, Manuel, Fondard, Emeline, Derambure, Céline, Avenel, Gilles, Golinski, Marie-Laure, Verdet, Mathieu, Boyer, Olivier, Caillot, Frédérique, Musette, Philippe, Lequerré, Thierry, Vittecoq, Olivier
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824496/
https://ncbi.nlm.nih.gov/pubmed/27025255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23796
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