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Direct and Propagated Effects of Small Molecules on Protein–Protein Interaction Networks

Networks of protein–protein interactions (PPIs) link all aspects of cellular biology. Dysfunction in the assembly or dynamics of PPI networks is a hallmark of human disease, and as such, there is growing interest in the discovery of small molecules that either promote or inhibit PPIs. PPIs were once...

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Veröffentlicht in:Front Bioeng Biotechnol
Hauptverfasser: Cesa, Laura C., Mapp, Anna K., Gestwicki, Jason E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547496/
https://ncbi.nlm.nih.gov/pubmed/26380257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2015.00119
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